Let's go back to the basics and look at the meaning of the word "Issue". According to online Cambridge Advanced Learner's Dictionary, issue is,
A subject or problem which people are thinking and talking about.In the context of a software development, issue could be anything that people are thinking and talking about in relation to the project. This gives us a very good idea on what an issue is. That is,
A subject or problem which people are thinking and/or talking about a software product or project.This interpretation is general but should be adequate to cover what most of us perceived as an issue.